The New York Times’\u0131n haberine g\u00f6re, bilim insanlar\u0131 ABD merkezli \u00e7ok uluslu bir ara\u015ft\u0131rmada otoimm\u00fcn hastal\u0131klar\u0131n genetik nedenlerini ara\u015ft\u0131rd\u0131.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, v\u00fccuttaki \u00e7o\u011fu proteinin \u00fcretimine dair bilgiyi ta\u015f\u0131yan X e\u015fey kromozomunun kad\u0131nlarda 2 tane bulunmas\u0131 gerek\u00e7esiyle, X \u00e7iftinden birindeki bilginin “Xist” ad\u0131ndaki RNA ipli\u011fi sayesinde bask\u0131land\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n
Otoimm\u00fcn hastal\u0131klarda etkili olan bir\u00e7ok proteinin ayr\u0131ca “Xist”in s\u00f6z konusu i\u015flevleri bask\u0131lamas\u0131na yard\u0131mc\u0131 oldu\u011funu belirleyen ara\u015ft\u0131rmac\u0131lar, proteinin i\u015fleyi\u015fini laboratuvarda mercek alt\u0131na ald\u0131.<\/p>\n
Bilim insanlar\u0131, erkek farelerin geneti\u011fini de\u011fi\u015ftirerek di\u015fi fareler gibi Xist sentezlemesini sa\u011flad\u0131klar\u0131nda, erkeklerin di\u015filerden daha fazla otoimm\u00fcn hastal\u0131\u011fa sahip oldu\u011funu aktard\u0131.<\/p>\n
Farelerden elde edilen verileri insanlara uyarlamak i\u00e7in 17 ki\u015filik kontrol grubuna ek olarak 100’\u00fcn \u00fczerinde dermatomiyozit, sistemik skleroz ve lupus hastas\u0131 don\u00f6rden al\u0131nan kan numunesini inceleyen ara\u015ft\u0131rmac\u0131lar, lupus ve di\u011fer otoimm\u00fcn bozukluklara sahip ki\u015filerin Xist ile ili\u015fkili antikor seviyesinin y\u00fcksek oldu\u011funu belirledi.<\/p>\n
Ara\u015ft\u0131rma yazarlar\u0131ndan Howard Chang, v\u00fccutta her g\u00fcn ger\u00e7ekle\u015fen normal h\u00fccre \u00f6l\u00fcm\u00fc s\u0131ras\u0131nda kan dola\u015f\u0131m\u0131na bir\u00e7ok bile\u015fi\u011fin sal\u0131nd\u0131\u011f\u0131n\u0131 ve bu “h\u00fccresel art\u0131\u011f\u0131n” kad\u0131nlarda \u00e7ok daha fazla Xist ve ilgili proteinleri bar\u0131nd\u0131rd\u0131\u011f\u0131n\u0131 vurgulad\u0131.<\/p>\n
Chang, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin, Xist molek\u00fcl\u00fc ve ba\u011fl\u0131 oldu\u011fu proteinleri v\u00fccuda zararl\u0131 olarak i\u015faretledi\u011fi durumlarda otoimm\u00fcn hastal\u0131klar\u0131n ortaya \u00e7\u0131kt\u0131\u011f\u0131n\u0131 kaydetti.<\/p>\n
Ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131, “Cell” dergisinde yay\u0131mland\u0131.<\/p>\n
Kaynak: AA<\/p>\n","protected":false},"excerpt":{"rendered":"
Bilim insanlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kendi h\u00fccre, doku veya organlar\u0131na sald\u0131rd\u0131\u011f\u0131 otoimm\u00fcn hastal\u0131klar\u0131n kad\u0131nlarda daha s\u0131k…<\/p>\n","protected":false},"author":1,"featured_media":76887,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17955,1,4,17438],"tags":[],"class_list":["post-76886","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kadin","category-manset","category-saglik","category-yasam"],"views":63,"_links":{"self":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/76886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/comments?post=76886"}],"version-history":[{"count":1,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/76886\/revisions"}],"predecessor-version":[{"id":76888,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/76886\/revisions\/76888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/media\/76887"}],"wp:attachment":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/media?parent=76886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/categories?post=76886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/tags?post=76886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}