Bilim insanlar\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde “do\u011fal antibiyotiklerin kayna\u011f\u0131 olabilecek” yeni bir b\u00f6l\u00fcm ke\u015ffetti.<\/p>\n
BBC’nin haberine g\u00f6re, Avrupa Ara\u015ft\u0131rma Konseyi (ERC) taraf\u0131ndan desteklenen uzmanlar, bula\u015f\u0131c\u0131 hastal\u0131klar\u0131n tedavisini d\u00f6n\u00fc\u015ft\u00fcrebilecek yeni bir ke\u015fif yapt\u0131.<\/p>\n
Ke\u015fif, “Nature” dergisinde “protein at\u0131klar\u0131 insan h\u00fccrelerinin savunma stratejisi olarak antibiyotiklere d\u00f6n\u00fc\u015ft\u00fcr\u00fcld\u00fc” ba\u015fl\u0131kl\u0131 makalede yay\u0131mland\u0131.<\/p>\n
Buna g\u00f6re uzmanlar, h\u00fccrelerde proteinleri par\u00e7alayan “proteazomlar\u0131n” bakteriyel enfeksiyona kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sistemine katk\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 saptad\u0131.<\/p>\n
“\u00c7\u00f6p kar\u0131\u015ft\u0131rma” ad\u0131 verilen bilimsel s\u00fcre\u00e7 kapsam\u0131nda laboratuvarda b\u00fcy\u00fcyen bakteriler ve sepsisli fareler \u00fczerinde test yap\u0131ld\u0131.<\/p>\n
Bu s\u00fcre\u00e7te laboratuvarda h\u00fccreleri al\u0131n\u0131p proteazomu devre d\u0131\u015f\u0131 b\u0131rak\u0131lan Salmonella gibi bakterilerin enfekte edilmesi daha kolay hale geldi.<\/p>\n
Proteinleri geri d\u00f6n\u00fc\u015ft\u00fcren proteazomun, bakteri \u00f6ld\u00fcr\u00fcc\u00fc kimyasallardan olu\u015fan bir depo ortaya \u00e7\u0131karan gizli bir mekanizmas\u0131 oldu\u011fu belirlendi.<\/p>\n
H\u00fccre i\u00e7inde proteazomlar\u0131n, bakterileri tespit edebildi\u011fi ve bunun b\u00fcy\u00fcmesini durdurmak i\u00e7in kar\u015f\u0131 savunmalar olu\u015fturabildi\u011fi bulundu.<\/p>\n
Makalede, “Bu bulgular, bula\u015f\u0131c\u0131 hastal\u0131klarla m\u00fccadelede daha \u00f6nce tan\u0131mlanmam\u0131\u015f tedavi stratejilerinin \u00f6n\u00fcn\u00fc a\u00e7abilir” ifadesi kullan\u0131ld\u0131.<\/p>\n
Ba\u011f\u0131\u015f\u0131kl\u0131k sistemindeki yeni ke\u015ffin, “antimikrobiyal diren\u00e7li (AMR) enfeksiyonlarla m\u00fccadelede” yayg\u0131n antibiyotiklere alternatif olu\u015fturabilece\u011fi iddia edildi.<\/p>\n
Weizmann Bilim Enstit\u00fcs\u00fcnden Prof. Yifat Merbl, ke\u015ffin “bakteriyel enfeksiyona kar\u015f\u0131 savunma sa\u011flayan yeni ba\u011f\u0131\u015f\u0131kl\u0131k mekanizmas\u0131” oldu\u011funu belirtti.<\/p>\n
Merbl, “Bu, v\u00fccudumuzun her yerinde, t\u00fcm h\u00fccrelerde ger\u00e7ekle\u015fiyor ve tamamen yeni bir potansiyel do\u011fal antibiyotik s\u0131n\u0131f\u0131 olu\u015fturuyor.” dedi.<\/p>\n
Imperial College London Ya\u015fam Bilimleri B\u00f6l\u00fcm Ba\u015fkan\u0131 Profes\u00f6r Danile Davis, a\u00e7\u0131klamas\u0131nda, bulgular\u0131n “olduk\u00e7a ilgin\u00e7” oldu\u011funu kaydetti.<\/p>\n
Ke\u015ffin “yeni bir antibiyotik kayna\u011f\u0131na d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinin zaman alaca\u011f\u0131n\u0131” kaydeden Davis, daha fazla test yap\u0131lmas\u0131 gerekti\u011fine dikkati \u00e7ekti.<\/p>\n
Davis, bunun yeni bir antibiyotik kayna\u011f\u0131na d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinin “hen\u00fcz test edilmesi gereken ve zaman alabilecek” bir d\u00fc\u015f\u00fcnce oldu\u011funu bildirdi.<\/p>\n
Hastal\u0131k ve enfeksiyonlar\u0131n yayg\u0131n tedavilerine yan\u0131t vermemesi olarak bilinen “AMR” k\u00fcresel bir sa\u011fl\u0131k sorunu olarak kabul ediliyor.<\/p>\n
Ulusal Denetim Ofisi (NAO) raporuna g\u00f6re, AMR her y\u0131l \u0130ngiltere’de 7 bin 600 \u00f6l\u00fcmden do\u011frudan, 35 bin 200 \u00f6l\u00fcmden dolayl\u0131 olarak sorumlu.<\/p>\n
\u0130ngiltere Sa\u011fl\u0131k G\u00fcvenlik Ajans\u0131 yetkilisi Dr. Colin Brown ocakta, ajans\u0131n \u00fclke i\u00e7i ve d\u0131\u015f\u0131nda artan AMR vir\u00fcs\u00fc riskine kar\u015f\u0131 teyakkuzda oldu\u011funu s\u00f6ylemi\u015fti.<\/p>\n
AMR’nin her y\u0131l k\u00fcresel \u00e7apta 1 milyondan fazla \u00f6l\u00fcme neden oldu\u011funa kaydeden Brown, “Eylemde bulunulmazsa, hayat kurtar\u0131c\u0131 tedavilerin bulunabilirli\u011fi d\u00fc\u015fecek ve enfeksiyonlar\u0131 azaltma yetene\u011fimiz azalacak” demi\u015fti.<\/p>\n
Kaynak: AA<\/p>\n","protected":false},"excerpt":{"rendered":"
Ke\u015ffin, “antibiyotik diren\u00e7li enfeksiyonlarla m\u00fccadelede” yayg\u0131n antibiyotiklere alternatif olu\u015fturabilece\u011fi iddia ediliyor. Bilim insanlar\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde…<\/p>\n","protected":false},"author":1,"featured_media":77548,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,4,17438],"tags":[],"class_list":["post-77547","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-manset","category-saglik","category-yasam"],"views":29,"_links":{"self":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/77547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/comments?post=77547"}],"version-history":[{"count":1,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/77547\/revisions"}],"predecessor-version":[{"id":77549,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/posts\/77547\/revisions\/77549"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/media\/77548"}],"wp:attachment":[{"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/media?parent=77547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/categories?post=77547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haberegider.com\/blog\/wp-json\/wp\/v2\/tags?post=77547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}